Factors associated with a higher rate of distant failure after primary treatment for glioblastoma

摘要: Our purpose was to analyze the pattern of failure in glioblastoma (GBM) patients at first recurrence after radiotherapy and temozolomide its relationship with different factors. From 77 consecutive GBM treated our institution fluorescence guided surgery standard radiochemotherapy, 58 recurrences were identified included a retrospective review. Clinical data including age, Karnofsky performance score, preoperative tumor volume location, extend resection, MGMT promoter methylation status, time progression (PFS), overall survival (OS) adjuvant therapies reviewed for every patient. Recurrent location respect original lesion end point study. The local only 65.5 % non-local 34.5 %. univariate multivariate analysis showed that greater T1 gadolinium enhanced sequences, variable statistical signification (p < 0.001) increased rate recurrences, although complete resection enhancing presented more frequently. PFS longer (13.8 vs. 6.4 months; p = 0.019, log-rank). However, OS not significantly both groups (24.0 19.3 local; p = 0.9). Rate series radiochemotherapy higher than previously published GBM, especially PFS. Greater associated recurrences.