Ready access to enantiopure 5-substituted-3-pyrrolin-2-ones from N-benzyl-2,3-O-isopropylidene-d-glyceraldehyde nitrone (BIGN)
作者： Pedro Merino , Elena Castillo , Santiago Franco , Francisco L Merchan , Tomas Tejero
DOI: 10.1016/S0957-4166(98)00150-5
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摘要: Abstract The reaction of the lithiated salt methyl propiolate with N -benzyl-2,3- O -isopropylidene- d -glyceraldehyde nitrone (BIGN) afforded corresponding propargyl hydroxylamines in a stereocontrolled way depending on nature Lewis acid used as an additive. Subsequent reduction obtained provided chiral 5-substituted-3-pyrrolin-2-ones, high overall yields.
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