Strictly regio- and stereo-controlled α-alkenylation of bicyclic enone derivatives via palladium-catalyzed cross coupling and its application to a formal synthesis of (±)-carbacyclin
作者： Ei-ichi Negishi , Milan Pour , Frederik E. Cederbaum , Martin Kotora
DOI: 10.1016/S0040-4020(98)00347-0
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摘要: Abstract A formal synthesis of carbacylin was achieved by preparing a known advanced intermediate 15 via Zr-promoted enyne bicyclization-carbonylation, Pd-catalyzed α-alkenylation bicyclic enones, and conjugate reduction.
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