Dietary protein, calcium metabolism, and skeletal homeostasis revisited

摘要: High dietary protein intakes are known to increase urinary calcium excretion and, if maintained, will result in sustained hypercalciuria. To date, the majority of balance studies humans have not detected an effect on intestinal absorption or serum parathyroid hormone. Therefore, it is commonly concluded that source excess increased bone resorption. Recent from our laboratory indicate alterations can, fact, profoundly affect absorption. In short-term trials healthy adults, we fixed intake at 20 mmol/d while was 0.7 2.1 g/kg. Increasing induced hypercalciuria women [from 3.4 +/- 0.3 ( SE) during low-protein 5.4 0.4 high-protein diet]. The accompanied by a significant 18.4 1.3% 26.3 1.5% (as determined dual stable isotopic methodology). Dietary and below 0.8 g/kg were associated with probable reduction sufficient cause secondary hyperparathyroidism. long-term consequences these diet-induced changes mineral metabolism known, but diet could be detrimental skeletal health. Of concern several recent epidemiologic demonstrate reduced density rates loss individuals habitually consuming diets. Studies needed determine whether low directly resorption, formation, both.