Steroid Hormones and Hormone Receptors in Neoplastic Diseases

摘要: Publisher Summary This chapter describes the role of steroid hormones and hormone receptors in promoting growth neoplastic diseases. There is considerable evidence that different classes tumor cells are under autoregulatory control; thus, dominant factor regulating receptor levels appears to be cognate hormonal ligand itself. The effects on mediated by interact with DNA regulate gene transcription. Estrogens have a direct mitogenic effect breast cancer shorten duration their cell cycle. In vivo, factors, estrogen probably act concert other systemic mitogens promote growth. addition intrinsic oncogenic potential, may involved pathogenesis through interaction environmental toxins. Both progesterone detectable endometrial adenocarcinoma cells, where level these correlates degree cellular differentiation. Immunocytochemical assays fresh frozen sections carcinoma tissue demonstrate heterogeneity terms distribution receptors.