Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control

摘要: The respective roles of the neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) in modulating social cognition for therapeutic intervention autism spectrum disorder have not been fully established. In particular, while numerous studies demonstrated effects promoting attention role AVP has examined. present study employed a randomized, double-blind, placebo (PLC)-controlled between-subject design to explore social- emotion-specific on both bottom-up top-down processing with validated emotional anti-saccade eye-tracking paradigm 80 male subjects (PLC = 40, 40). Our findings showed that increased error rate (angry, fearful, happy, neutral sad faces) but non-social (oval shapes) stimuli during condition reduced rates pro-saccade condition. Comparison these previous (sample size: PLC 33, OXT 33) using intranasal revealed similar two peptides errors significantly greater effect pro-saccades. Both also produced post-task anxiolytic by reducing state anxiety. Together suggested decrease goal-directed control salient more potently attentional processing.