Continuous Noninvasive Orthostatic Blood Pressure Measurements and Their Relationship with Orthostatic Intolerance, Falls, and Frailty in Older People

摘要: OBJECTIVES: To identify morphological orthostatic blood pressure (BP) phenotypes in older people and assess their correlation with intolerance (OI), falls, frailty to compare the discriminatory performance of a classification two established hypotension (OH) definitions: consensus (COH) initial (IOH). DESIGN: Cross-sectional. SETTING: Geriatric research clinic. PARTICIPANTS: Four hundred forty-two participants (mean age 72, 72% female) without dementia or risk factors for autonomic neuropathy. MEASUREMENTS: Active lying-to-standing test monitored using continuous noninvasive BP monitor. For classification, four systolic variables were extracted (delta (baseline - nadir) maximum percentage baseline recovered by 30 seconds 1 2 minutes) 5-second averages method entered K-means cluster analysis (three clusters). Main outcomes OI, falls (≥1 past 6 months), (modified Fried criteria). RESULTS: The clusters small drop, fast overrecovery (n=112); medium slow recovery (n=238); large nonrecovery (n=92). Their characterization revealed an increasing OI gradient (17.9%, 27.5%, 44.6% respectively, P Language: en