STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis
作者： Ayushi Vashisht , Mohamed Trebak , Rajender K. Motiani
DOI: 10.1152/AJPCELL.00064.2015
关键词:
摘要: Calcium (Ca2+) regulates a plethora of cellular functions including hallmarks cancer development such as cell cycle progression and migration. Receptor-regulated calcium rise in nonexcitable cells occurs through store-dependent well store-independent Ca2+ entry pathways. Stromal interaction molecules (STIM) Orai proteins have been identified critical constituents both these influx STIMs Orais emerged targets for therapeutics their altered expression function shown to contribute tumorigenesis. Recent data demonstrate that they play vital role metastasis variety tumor types breast, prostate, cervical, colorectal, brain, skin tumors. In this review, we will retrospect the supporting key STIM1, STIM2, Orai1, Orai3 tumorigenesis discuss potential targeting therapy.
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