Serendiptic Modulation of Transmitter Release: Extracellular Calcium Inhomogeneity

摘要: The amplitude and quantal content of synaptic potentials at the neuromuscular synapse frog are extremely sensitive to calcium concentration in extracellular solution (Jenkinson, 1957; Dodge & Rahamimoff, 1967). When bathing is clamped a constant level by employing suitable buffer, average endplate potential reduced relative those measured Ringer with similar yet unbuffered free (Ginsburg 1983). This may indicate that space inhomogenous, normally, its cleft probably higher than bulk solution. Possible origins for inhomogeneity be matrix components transporters situated membranes facing cleft; changes their distributions densities provide nerve terminal energetically economical mechanisms self-regulating transmission.