A time-dependent non-Newtonian extension of a 1D blood flow model

摘要: Abstract Blood pulsatility, aneurysms, stenoses and general low shear stress hemodynamics enhance non-Newtonian blood effects which generate local changes in the space-time evolution of pressure, flow rate cross-sectional area elastic vessels. Even though these are known to cause global unexpected hemodynamical behaviors, all one-dimensional (1D) models built under Newtonian fluid hypothesis. In this work, we present a time-dependent extension 1D model, able describe variations viscous behavior blood. The rheological model is based on simplified Maxwell viscoelastic equation for with structure dependent coefficients. We compare numerical predictions experimental data available literature. Specifically, explore four well documented protocols show that results predicted by single artery accurately compare, both qualitatively quantitatively, steady unsteady stresses measured experimentally. then use compute idealized healthy pathological symmetric asymmetric networks increasing size. aggregation occurs such occurs, leading behaviors especially presence pathologies. This will be useful future improve our understanding large-scale micro- macro-circulation networks.