Protein chemical synthesis by serine and threonine ligation
作者： Y. Zhang , C. Xu , H. Y. Lam , C. L. Lee , X. Li
关键词:
摘要: An efficient method has been developed for the salicylaldehyde ester-mediated ligation of unprotected peptides at serine (Ser) or threonine (Thr) residues. The utility this peptide approach demonstrated through convergent syntheses two therapeutic peptides––ovine-corticoliberin and Forteo––and human erythrocyte acylphosphatase protein (∼11 kDa). requisite ester precursor is prepared in an epimerization-free manner via Fmoc–solid-phase synthesis.
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