Protective role of thymoquinone against liver damage induced by tamoxifen in female rats
作者： Ghada M. Suddek
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摘要: One of the major reasons for terminating a clinical trial is liver toxicity induced by chemotherapy. Tamoxifen (TAM) an anti-estrogen used in treatment and prevention hormone-dependent breast cancer. therapy may cause hepatic injury. The seeds Nigella sativa, which contain active ingredient thymoquinone (TQ), have been folk medicine diverse ailments. TQ reported to possess anticancer hepatoprotective effects. In this study, protective effects against TAM-induced hepatotoxicity female rats were evaluated. Four groups used: control; TAM; TQ; TAM+TQ. TAM (45 mg·(kg body mass)–1·day–1, intraperitoneal injection (i.p.), 10 consecutive days) resulted elevated serum levels alanine aminotransferase, aspartate alkaline phosphatase, lactate dehydrogenase, total bilirubin, gamma glutamyl transferase, as well depletion reduced glutathione accumulation lipid peroxides. Also, trea...
nrcresearchpress.com参考文章(29)
Liane Rabinowich, Oren Shibolet, Drug Induced Steatohepatitis: An Uncommon Culprit of a Common Disease. BioMed Research International. ,vol. 2015, pp. 168905- 168905 ,(2015) , 10.1155/2015/168905
Peter Houghton, Rema Zarka, Beatriz de las Heras, J. Hoult, Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Medica. ,vol. 61, pp. 33- 36 ,(1995) , 10.1055/S-2006-957994
Fabiana Caballero, Esther Gerez, Leda Oliveri, Nora Falcoff, Alcira Batlle, Elba Vazquez, On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice. The International Journal of Biochemistry & Cell Biology. ,vol. 33, pp. 681- 690 ,(2001) , 10.1016/S1357-2725(01)00056-5
Ayşin Öge, Ebru Demırel Sezer, Mert Özgönül, Firat Bayraktar, Eser Yildirim Sözmen, None, The effects of estrogen and raloxifene treatment on the antioxidant enzymes and nitrite-nitrate levels in brain cortex of ovariectomized rats. Neuroscience Letters. ,vol. 338, pp. 217- 220 ,(2003) , 10.1016/S0304-3940(02)01416-7
Ashwag A. Albukhari, Hana M. Gashlan, Hesham A. El-Beshbishy, Ayman A. Nagy, Ashraf B. Abdel-Naim, Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats. Food and Chemical Toxicology. ,vol. 47, pp. 1689- 1695 ,(2009) , 10.1016/J.FCT.2009.04.021
Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry. ,vol. 95, pp. 351- 358 ,(1979) , 10.1016/0003-2697(79)90738-3
Stefan L. Marklund, Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB/c mice. Mutation Research. ,vol. 148, pp. 129- 134 ,(1985) , 10.1016/0027-5107(85)90216-7
Ioannis S Elefsiniotis, Konstantinos D Pantazis, Anastasios Ilias, Loukas Pallis, Anargiros Mariolis, Irene Glynou, Helen Kada, Antonios Moulakakis, Tamoxifen induced hepatotoxicity in breast cancer patients with pre-existing liver steatosis: the role of glucose intolerance. European Journal of Gastroenterology & Hepatology. ,vol. 16, pp. 593- 598 ,(2004) , 10.1097/00042737-200406000-00013
George L. Ellman, Tissue sulfhydryl groups Archives of Biochemistry and Biophysics. ,vol. 82, pp. 70- 77 ,(1959) , 10.1016/0003-9861(59)90090-6
Chia-Pu Lee, Ping-Hsiao Shih, Chin-Lin Hsu, Gow-Chin Yen, Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats Food and Chemical Toxicology. ,vol. 45, pp. 888- 895 ,(2007) , 10.1016/J.FCT.2006.11.007