Effect of Testosterone Propionate on the Adrenals and on the Incidence of Mammary Cancer in the RIII Strain of Mice

摘要: The hormonal relationship that Cramer and Horning (6, 8, 9) believe to exist between brown degeneration of the adrenals carcinoma mammae in high tumor strain mice has been questioned by other observers, but not definitely disproved. Details may be found papers Dobrovolska~a-Zavadskai"a her group (15-17); Lacassagne Raynaud (25, 26); Blaisdell, Gardner, Strong (1); Bonser (3); Kreyberg (23). This occurs frequently at an early age female a strain, according (8) Dobrovolskai'a-Zavadskai'a (17), is seen also tumorfree males same later age. It described Whitehead (31), Martin (28), Howard-Miller (21 ), Burrows (5), Daughady (11), Deanesly (12) as cortico-medullary junction, periphery medulla, or medial part zona reticularis. change significantly begins x-zone, which, Howard-Miller, "A transitory zone showing sex relationships mice." appearance around x-zone various strains after estrinization (4, 5), (6), induction mammary tumors similar reported (10), associates (2), (24), Twombly (30), Gardner (18) warranted further studies on this apparent relationship. (5) states effect castration, pregnancy, estrogen presence absence suggests it influenced testosterone progesterone, notes these hormones seem hasten involution absorption normally mice. points out castration male causes reappearance converting adrenal type. Woolley, Fekete, Little (32) have observed nodular hyperplasia ovariectomized show return effect. (28) noted dis-