Prioritization of reproductive toxicants in unconventional oil and gas operations using a multi-country regulatory data-driven hazard assessment.

摘要: Abstract Background Recent trends have witnessed the global growth of unconventional oil and gas (UOG) production. Epidemiologic studies suggested associations between proximity to UOG operations with increased adverse birth outcomes cancer, though specific potential etiologic agents not yet been identified. To perform effective risk assessment chemicals used in production, first step hazard identification followed by prioritization specifically for reproductive toxicity, carcinogenicity mutagenicity is crucial an evidence-based approach. date, there no single classification list based on United Nations Globally Harmonized System (GHS), countries applying GHS standards generate their own chemical lists. A current challenge prioritization, particularly a multi-national industry, inconsistent which may result misjudgment public health risks. We present novel approach toxicants found using publicly available regulatory databases. Methods toxicity 157 UOG-related identified as or developmental previous publication was assessed eleven governmental agency If discordance classifications across agencies, most stringent assigned. Chemicals category known presumed human were further evaluated germ cell government classifications. scoring system utilized assign numerical values health, cancer mutation endpoints. Using Cytoscape analysis, both qualitative quantitative results presented visually readily identify high priority evidence multiple effects. Results observed substantial inconsistencies among 11 By adopting within countries, 43 classified (GHS Category 1), while 31 suspected 2). The subjected analysis carcinogenic mutagenic properties. Calculated scores visualization yielded several including potassium dichromate, cadmium, benzene ethylene oxide. Conclusions Our findings reveal diverging agencies. Adoption application provides useful prioritize other industries exposure assessments selection safer alternatives.