Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence.

摘要: Addiction is a chronic brain disorder that progressively invades all aspects of personal life. Accordingly, addiction to opiates severely impairs interpersonal relationships, and the resulting social isolation strongly contributes severity chronicity disease. Uncovering new therapeutic strategies address this aspect therefore great clinical relevance. We recently established mouse model heroin in which, following exposure, 'abstinent' mice develop strong long-lasting avoidance phenotype. Here, we explored compared efficacy two pharmacological interventions model. Because studies indicate some antidepressants on emotional dysfunction associated with addiction, first used 4-week treatment serotonergic antidepressant fluoxetine, as reference. In addition, considering prodepressant effects kappa opioid receptor signaling, also investigated antagonist norbinaltorphimine (norBNI). Finally, assessed whether fluoxetine norBNI could reverse abstinence-induced after it has established. Altogether, our results show interspaced administrations are sufficient both prevent impairment abstinent animals. Therefore, antagonism may represent useful approach alleviate addicted individuals.