Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis.
作者： Francesco Cavazzini , Jose Angel Hernandez , Alessandro Gozzetti , Antonella Russo Rossi , Cristiano De Angeli
DOI: 10.1111/J.1365-2141.2008.07227.X
关键词:
摘要: Immunophenotypic studies, fluorescence in situ hybridization (FISH) and conventional karyotyping were used to define the clinicobiological significance of 14q32 translocations involving immunoglobulin gene locus (14q32/IGH) 252 chronic lymphocytic leukaemia (CLL) patients. The following regions studied: 13q14, centromere 12, 6q21; 11q22/ATM; 17p13/TP53, 14q32/IGH. Patients classified as group 1 (favourable, i.e. 13q-single or normal), 2 (intermediate risk, +12, 6q-, 1-2 anomalies), 3 (unfavourable, 17p-, 11q-, complex karyotype), 4 (14q32/IGH translocation). Endpoints treatment-free survival (TFS) overall (OS). One hundred ten patients included 1, 99 2, 25 18 4. 14q32/IGH translocation partners identified eight cases (BCL2 five cases, BCL11A, CCND3 CDK6 one case each). showed shorter TFS versus groups (25% treated at months vs. 12 (P = 0.02) 20 0.002), respectively) OS dead 50 0.0003) >60 < 0.0001) respectively. maintained prognostic multivariate analysis on 0.025) 0.001), along with advanced stage CD38+. These findings show that predicts for an unfavourable outcome CLL this cytogenetic subset might be a separate entity hierarchical classification CLL.
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