Options in Hypersensitivity Reactions to Chemotherapeutics

摘要: Chemotherapeutic drugs still represent a gold standard for the treatment of neoplastic disease. They can induce hypersensitivity reactions and are third leading cause fatal drug-induced anaphylaxis in USA. This article has tried to highlight summarize most recent scientific progress concerning risk factors, pathogenesis, diagnosis, these reactions. Identification patients at high developing allows stratification guide clinical decision-making. Therefore, researches evaluated possibility perform case platinum compounds taxanes. In addition, new data now available regarding role vitro test diagnosis platins drug provocation number chemotherapeutics. However, actually, allergological work-up includes very careful anamnesis patient characteristics reaction, whereas skin tests useful only few classes chemotherapy, namely salts probably Premedication, desensitization and, some cases, able prevent majority reactions, permitting administration effective therapy. Clearly, more studies needed better understand, diagnose, treat, To reach this aim, multidisciplinar approach cancer with potential allergies is needed.