The effect of GWAS identified BMI loci on changes in body weight among middle-aged Danes during a five-year period.

摘要: Objective Genome-wide association studies have identified genetic variants associating with BMI, however, it is un-clarified whether the same also influence body weight fluctuations. Methods Among 3,982 adult individuals that attended both a baseline and five-year follow-up examination in Danish Inter99 intervention study, risk score (GRS) was constructed based on 30 BMI to address associated changes. Moreover, examined effect of lifestyle changes modulated by GRS. Results The GRS strongly weight, per allele increase 0.45 (0.33-0.58) kg (P = 2.7 × 10−12), corresponding difference 3.41 (2.21-4.60) comparing highest (≥ alleles) lowest (≤ 26 tertile. No observed during five years. Changes lifestyle, including physical activity, diet smoking habits changes, no interactions observed. Conclusion The cross-sectionally, but not over period. Body were influenced independently GRS.