The effect of intracerebroventricular injection of beta amyloid peptide (1-42) on caspase-3 activity, lipid peroxidation, nitric oxide and NOS expression in young adult and aged rat brain.

摘要: AIM Intracerebroventricular (icv) administration of beta amyloid peptide (Aβ) in rats can be used to model certain aspects Alzheimer disease (AD).The purpose this study was examine the effects intracerebroventricular Aβ (1-42) injection on caspase-3 activity and expression nNOS iNOS, malondialdehyde (MDA), glutathione (GSH) NOx hippocampus, temporal cortex parietal cortex. MATERIAL AND METHODS Groups were defined as 1) young adult control, 2) injected adult, 3) aged control 4) group. Stereotaxic surgery performed. (5μg/1μl, each icv) administered bilateral intracerebroventricularly a single injection. RESULTS Caspase-3 significantly increased when compared with rats. lipid peroxidation both There an increase CONCLUSION The most significant seen hippocampus levels Aged- 1-42 However, nNOX decreased significantly.