New Perspectives in Clostridium difficile Disease Pathogenesis

摘要: Clostridium difficile is associated with a spectrum of clinical manifestations ranging from asymptomatic carriage to severe life-threatening pseudomembranous colitis. Current perspectives indicate that C pathogenesis multifactorial disease process dictated by pathogenic toxin production, gut microbial dysbiosis, and altered host inflammatory responses. This article summarizes recent findings underpinning the cellular molecular mechanisms regulating bacterial virulence sheds new light on critical roles immune response, intestinal microbiota, metabolome in mediating pathogenesis.