Epstein-Barr virus (EBV) activates NKL homeobox gene HLX in DLBCL
作者： Stefan Nagel , Cord C. Uphoff , Wilhelm G. Dirks , Claudia Pommerenke , Corinna Meyer
DOI: 10.1371/JOURNAL.PONE.0216898
关键词:
摘要: NKL homeobox genes encode developmental transcription factors regulating basic processes in cell differentiation. According to their physiological expression pattern early hematopoiesis and lymphopoiesis, particular members of this gene subclass constitute an NKL-code. B-cell specific NKL-code generate a regulatory network deregulation is implicated lymphomagenesis. Epstein-Barr virus (EBV) infects B-cells influences the activity signalling pathways including JAK/STAT several encoding regulators. Therefore, EBV-infection impacts pathogenesis outcome malignancies Hodgkin lymphoma diffuse large (DLBCL). Here, we isolated EBV-positive EBV-negative subclones from DLBCL derived line DOHH-2. These served as models investigate role EBV HHEX, HLX, MSX1 NKX6-3. We showed that EBV-encoded LMP1 LMP2A activated HLX via STAT3. turn repressed NKX6-3, SPIB IL4R which normally mediate plasma In addition, pro-apoptotic factor BCL2L11/BIM hence supported survival. Thus, aberrantly DLBCL, thereby disturbing both differentiation apoptosis. The results our study appreciate pathogenic malignancies.
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