Independent Negative Prognostic Role of TCF1 Expression within the Wnt/β-Catenin Signaling Pathway in Primary Breast Cancer Patients.
作者： Saponaro , Scarpi , Zito , Giotta , Silvestris
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摘要: The Wnt pathway is involved in the progression of breast cancer (BC). We aimed to evaluate expression some components (β-catenin, FZD4 (frizzled receptor 4), LRP5 (low-density lipoprotein receptor-related protein 5), LRP6, and TCF1 (T-cell factor 1)) detect potential associations with NHERF1 (Na+/H+ exchanger regulatory 1) protein. Besides, we assessed their impact on patients’ clinical outcome. evaluated 220 primary BC samples by immunohistochemistry (IHC) localization immunofluorescence. found a significant correlation between FZD4, LRP5, TCF1. Univariate analysis showed that overexpression β-catenin (p < 0.0001), = 0.0001 respectively) was related poor disease-free survival (DFS). A Kaplan-Meier confirmed univariate data DFS for cNHERF1+/FZD4+ 0.0007), cNHERF1+/LRP5+ 0.0002), cNHERF1+/LRP6+ cNHERF1+/TCF1+ phenotypes 0.0034). In multivariate analysis, an independent prognostic variable worse 0.009 p 0.027, respectively). conclusion, β-catenin, associated prognosis. Furthermore, first identified as outcome, indicating it new biomarker management patients. Also, proteins, both alone association NHERF1, suggests original biological significance studies.
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