C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells
作者： Kazuhiko Okumura , Akifumi Itoh , Emiko Isogai , Kimiharu Hirose , Yoichiro Hosokawa
DOI: 10.1016/J.CANLET.2004.04.006
关键词:
摘要: Mammalian myeloid and epithelial cells express many antimicrobiotic peptides that contribute to innate host defense against invading microbes. In the present study, a 27-mer peptide of C-terminal domain (hCAP18(109-135)) analogs antimicrobial human cathelicidin LL-37/human cationic protein 18 (hCAP18) were examined for tumoricidal activity. vitro results showed hCAP18(109-135) induced apoptosis in oral squamous cell carcinoma (OSCC), SAS-H1 cells. The mitochondrial depolarization cells, but not healthy gingival fibroblasts (HGF) keratinocyte line HaCaT Caspases activated during hCAP18(109-135)-induced indicate may induce caspase-independent OSCC normal can therefore be useful anti-tumor therapeutic agent treatment OSCC.
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