The Vascular Basement Membrane: A Niche for Insulin Gene Expression and β Cell Proliferation

摘要: Endocrine pancreatic β cells require endothelial signals for their differentiation and function. However, the molecular basis such remains unknown. Here, we show that cells, in contrast to exocrine do not form a basement membrane. Instead, by using VEGF-A, they attract which capillaries with vascular membrane next cells. We have identified laminins, among other proteins, as signals, promote insulin gene expression proliferation further demonstrate β1-integrin is required cell response laminins. The proposed mechanism explains why must interact it may apply cellular processes are required.