Loss of p120‐catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling

摘要: Metastatic breast cancer remains the chief cause of cancer-related death among women in Western world. Although loss cell-cell adhesion is key to progression, little known about underlying mechanisms that drive tumor invasion and metastasis. Here, we show somatic p120-catenin (p120) a conditional mouse model noninvasive mammary carcinoma results formation stromal-dense tumors resemble human metaplastic metastasize lungs lymph nodes. Loss p120 anchorage-dependent cell lines strongly promoted anoikis resistance through hypersensitization growth factor receptor (GFR) signaling. Interestingly, deletion also induced secretion inflammatory cytokines, feature likely underlies prometastatic microenvironment p120-negative carcinomas. Our establish preclinical platform develop tailored intervention regimens target GFR signals treat metastatic cancers.