Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis
作者： Gabriel Goméz
DOI: 10.1016/0016-5085(91)90703-N
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摘要: Abstract Folate deficiency has been associated with dysplasia in human cancer models. Patients ulcerative colitis commonly have decreased folate levels, which are partially due to sulfasalazine, a competitive inhibitor of absorption. To study the effect supplementation on risk or (neoplasia) colitis, records from 99 patients pancolitis for >7 yr and enrolled surveillance program were reviewed. Thirty-five neoplasia compared 64 whom was never found determine rate development using case-control methodology. At time index colonoscopy, older (43 ± 11 vs. 39 12 yr) had disease longer duration (20 8 15 7 yr, p
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