Bivariate GWAS scan identifies six novel loci associated with lipid levels and coronary artery disease
作者： Katherine M. Siewert , Benjamin F. Voight
DOI: 10.1101/319848
关键词:
摘要: Background- Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independently one another. Joint GWAS for two related phenotypes can lead to a higher-powered analysis detect variants contributing both traits. Methods Results- We performed bivariate discover novel loci heart disease, using CAD Meta-Analysis (122,733 cases 424,528 controls), traits, data from the Global Lipid Genetics Consortium (188,577 subjects). identified six previously unreported at significance (P
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