Anti-idiotypic sera against monoclonal anti-porcine growth hormone antibodies: production in rabbits and characterization of specificity.
作者： Catherine M. Cahill , Jack T. Rogers
DOI: 10.1080/01971529909349313
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摘要: Abstract Antisera were raised in rabbits against two mouse monoclonal anti-porcine growth hormone (pGH) antibodies. Anti-idiotypic antibodies isolated from rabbit sera by successive passage over immunoadsorbent columns of normal 1g (mIg), followed the specific immunizing and elution latter. Enzyme linked assay (ELISA) for anti-idiotype free idiotype established. While showing specificity their respective inducing monoclonals, anti-idiotypes also cross reacted varying degrees with other anti-pGH monoclonals regardless differences between antibodies, demonstrating presence a cross-reactive idiotype.
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