Synthetic peptide immunoassay distinguishes HIV type 1 and HIV type 2 infections
作者： J. Gnann , J. McCormick , S Mitchell , J. Nelson , M. Oldstone
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摘要: Efforts to solve the epidemiologic puzzle of AIDS in Africa are complicated by presence multiple human retroviruses. Simple serologic tests that unambiguously distinguish among infections these retroviruses essential. To end, a partially conserved immunoreactive epitope was identified transmembrane glycoproteins immunodeficiency viruses (HIV) types 1 and 2. Synthetic peptides derived from domains were used sensitive specific immunoassays detect antibodies sera patients infected with HIV-1 or HIV-2. By making single amino acid substitutions peptide, it possible demonstrate strain-specific antibody responses this epitope. Such custom-designed synthesized domain likely newly discovered HIV types, define infection strains, allow detection group-common antibodies.
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J W Gnann, J A Nelson, M B Oldstone, Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus. Journal of Virology. ,vol. 61, pp. 2639- 2641 ,(1987) , 10.1128/JVI.61.8.2639-2641.1987
R. Gallo, S. Salahuddin, M Popovic, G. Shearer, M Kaplan, B. Haynes, T. Palker, R Redfield, J Oleske, B Safai, al. et, Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS Science. ,vol. 224, pp. 500- 503 ,(1984) , 10.1126/SCIENCE.6200936
Hardy Kornfeld, Norbert Riedel, Gregory A. Viglianti, Vanessa Hirsch, James I. Mullins, Cloning of HTLV-4 and its relation to simian and human immunodeficiency viruses Nature. ,vol. 326, pp. 610- 613 ,(1987) , 10.1038/326610A0
F Barre-Sinoussi, J. Chermann, F Rey, M. Nugeyre, S Chamaret, J Gruest, C Dauguet, C Axler-Blin, F Vezinet-Brun, C Rouzioux, W Rozenbaum, L Montagnier, Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. ,vol. 220, pp. 868- 871 ,(1983) , 10.1126/SCIENCE.6189183
F. Barin, F. Denis, J.S. Allan, S. M'Boup, P. Kanki, T.H. Lee, M. Essex, SEROLOGICAL EVIDENCE FOR VIRUS RELATED TO SIMIAN T-LYMPHOTROPIC RETROVIRUS III IN RESIDENTS OF WEST AFRICA The Lancet. ,vol. 326, pp. 1387- 1389 ,(1985) , 10.1016/S0140-6736(85)92556-5
Nathan Clumeck, Jean Sonnet, Henri Taelman, Françoise Mascart-Lemone, Marc De Bruyere, Philippe Vandeperre, Jean Dasnoy, Luc Marcelis, Monique Lamy, Claude Jonas, Luc Eyckmans, Henri Noel, Michel Vanhaeverbeek, Jean-Paul Butzler, Acquired Immunodeficiency Syndrome in African Patients New England Journal of Medicine. ,vol. 310, pp. 492- 497 ,(1984) , 10.1056/NEJM198402233100804
François Clavel, Denise Guétard, Françoise Brun-Vézinet, Sophie Chamaret, Marie-Anne Rey, Maria Odette Santos-Ferreira, Anne G Laurent, Charles Dauguet, Christine Katlama, Christine Rouzioux, David Klatzmann, José Luis Champalimaud, Luc Montagnier, Isolation of a new human retrovirus from West African patients with AIDS Science. ,vol. 233, pp. 343- 346 ,(1986) , 10.1126/SCIENCE.2425430
F Brun-Vezinet, Ch Rouzioux, L Montagnier, S Chamaret, J Gruest, F Barré-Sinoussi, D Geroldi, JC Chermann, J McCormick, S Mitchell, P Piot, H Taelman, Kapita Bila Mirlangu, Odio Wobin, Mbendi N Miazebo P, Kayembe Kalambayi, C Bridts, J Desmyter, FM Feinsod, TC Quinn, Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS Science. ,vol. 226, pp. 453- 456 ,(1984) , 10.1126/SCIENCE.6238406
B. H. Hahn, M. A. Gonda, G. M. Shaw, M. Popovic, J. A. Hoxie, R. C. Gallo, F. Wong-Staal, Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 4813- 4817 ,(1985) , 10.1073/PNAS.82.14.4813
R. L. MARCIALIS, G. H. RIEKE, L. A. LEBOFSKY, The surface composition of charon: tentative identification of water ice. Science. ,vol. 237, pp. 1349- 1351 ,(1987) , 10.1126/SCIENCE.237.4820.1349