The Effect of Intermittent Atrial Tachyarrhythmia on Heart Failure or Death in Cardiac Resynchronization Therapy With Defibrillator Versus Implantable Cardioverter-Defibrillator Patients
作者： Anne-Christine Ruwald , Grzegorz Pietrasik , Ilan Goldenberg , Valentina Kutyifa , James P. Daubert
DOI: 10.1016/J.JACC.2013.10.074
关键词:
摘要: Objectives This study aimed to investigate the effect of both history intermittent atrial tachyarrhythmias (IAT) and in-trial IAT on risk heart failure (HF) or death comparing cardiac resynchronization therapy with defibrillator (CRT-D) implantable cardioverter-defibrillator (ICD) treatment in mildly symptomatic HF patients left bundle branch block (LBBB). Background Limited data exist regarding benefit CRT-D IAT. Methods The reducing HF/death was evaluated using multivariate Cox models incorporating presence of, respectively, a at baseline time-dependent development during follow-up 1,264 LBBB enrolled MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) study. Results overall beneficial versus ICD not significantly different between without (HR: 0.50, p = 0.028, HR: 0.46, Conclusions In study, clinical attenuated by prior tachyarrhythmias. (MADIT-CRT: Multicenter Therapy; NCT00180271).
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