Artificial diaccharide-protein conjugates as immunogens for the preparation of specific anti-salmonella O-antisera☆
作者： Göran Ekborg , Karin Eklind , Per J. Garegg , Birgitta Gotthammar , Hans Erik Carlsson
DOI: 10.1016/0019-2791(77)90295-6
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摘要: Abstract Disaccharides representing the antigenic determinants of O-antigenic polysaccharide chain Salmonella serogroups B and D were synthesized, covalently linked to bovine serum albumin as immunogenic carrier. Rabbits, immunized with these artificial antigens, produced antisera which shown by passive hemagglutination complement-midiated bactericidal assays, be specific superior conventional antisera. When used in indirect immunofluoresence tests for identification bacteria, also proved highly specific, correctly identifying all isolates.
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