Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal
作者： Anthony T. S. Lo , Noeris K. Salam , David E. Hibbs , Peter J. Rutledge , Matthew H. Todd
DOI: 10.1371/JOURNAL.PONE.0017446
关键词:
摘要: Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper zinc complexes were synthesized characterized. ligand its bound AT-rich DNA selectively over GC-rich DNA, thermodynamic profile of binding evaluated by isothermal titration calorimetry. metal, encapsulated in scorpion azamacrocyclic complex, did not affect binding, which dominated organic tail.
harvard.edu
paperity.org参考文章(127)
L. F. Lindoy, The chemistry of macrocyclic ligand complexes Cambridge University Press. ,(1989) , 10.1017/CBO9780511564376
Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery, Deborah J. Burks, Jian-Ming Ren, Stephen Previs, Yitao Zhang, Dolores Bernal, Sebastian Pons, Gerald I. Shulman, Susan Bonner-Weir, Morris F. White, Disruption of IRS-2 causes type 2 diabetes in mice Nature. ,vol. 391, pp. 900- 904 ,(1998) , 10.1038/36116
Stephen Neidle, DNA minor-groove recognition by small molecules (up to 2000) Natural Product Reports. ,vol. 18, pp. 291- 309 ,(2001) , 10.1039/A705982E
Vinod K. Misra, Kim A. Sharp, Richard A. Friedman, Barry Honig, Salt effects on ligand-DNA binding: Minor groove binding antibiotics Journal of Molecular Biology. ,vol. 238, pp. 245- 263 ,(1994) , 10.1006/JMBI.1994.1285
Shin Aoki, Eiichi Kimura, Zinc−Nucleic Acid Interaction Chemical Reviews. ,vol. 104, pp. 769- 788 ,(2004) , 10.1021/CR020617U
Warren S. Wade, Milan Mrksich, Peter B. Dervan, Design of peptides that bind in the minor groove of DNA at 5'-(A,T)G(A,T)C(A,T)-3' sequences by a dimeric side-by-side motif Journal of the American Chemical Society. ,vol. 114, pp. 8783- 8794 ,(1992) , 10.1021/JA00049A006
Jurij Lah, Gorazd Vesnaver, Binding of Distamycin A and Netropsin to the 12mer DNA Duplexes Containing Mixed AT·GC Sequences with At Most Five or Three Successive AT Base Pairs† Biochemistry. ,vol. 39, pp. 9317- 9326 ,(2000) , 10.1021/BI000748U
Xin Chen, Boopathy Ramakrishnan, Sambhorao T. Rao, Muttaiya Sundaralingam, Binding of two distamycin A molecules in the minor groove of an alternating B–DNA duplex Nature Structural & Molecular Biology. ,vol. 1, pp. 169- 175 ,(1994) , 10.1038/NSB0394-169
Patricia C Weber, F Raymond Salemme, Applications of calorimetric methods to drug discovery and the study of protein interactions. Current Opinion in Structural Biology. ,vol. 13, pp. 115- 121 ,(2003) , 10.1016/S0959-440X(03)00003-4
Philip E. Pjura, Kazimierz Grzeskowiak, Richard E. Dickerson, Binding of Hoechst 33258 to the minor groove of B-DNA. Journal of Molecular Biology. ,vol. 197, pp. 257- 271 ,(1987) , 10.1016/0022-2836(87)90123-9