Topical treatments for fungal infections of the skin and nails of the foot.

摘要: Background Fungal infections of the feet normally occur in outermost layer skin (epidermis). The between toes is a frequent site infection which can cause pain and itchiness. Fungal nail (onychomycosis) affect entire plate. Objectives To assess effects topical treatments successfully treating (rate treatment failure) fungal toenails preventing recurrence. Search methods We searched Cochrane Skin Group Specialised Register (January 2005), Central Controlled Trials (The Library Issue 1, MEDLINE EMBASE (from inception to January 2005). We screened Science Citation Index, BIOSIS, CAB - Health Healthstar, CINAHL DARE, NHS Economic Evaluation Database EconLit (March Bibliographies were searched. Selection criteria Randomised controlled trials (RCTs) using participants who had mycologically diagnosed nails foot. Data collection analysis Two authors independently summarised included appraised their quality reporting structured data extraction tool. Main results Of 144 identified papers, 67 met inclusion criteria. Placebo-controlled yielded following pooled risk ratios (RR) failure for infections: allylamines RR 0.33 (95% CI 0.24 0.44); azoles 0.30 0.20 0.45); ciclopiroxolamine 0.27 0.11 0.66); tolnaftate 0.19 0.08 butenafine undecanoates 0.29 0.12 0.70). Meta-analysis 11 comparing showed ratio 0.63 0.42 0.94) favour allylamines. Evidence management sparser. There some evidence that are both effective but they need be applied daily prolonged periods (at least one year). six provided has poor cure rates amorolfine might substantially more research required. Authors' conclusions Placebo-controlled athlete's foot consistently produce much higher percentages than placebo. Allylamines slightly now available OTC. Further into effectiveness antifungal agents required.