IgA deficiency and autoimmunity

摘要: IgA is the most abundant immunoglobulin in human body, and performs a very specialized role which involves mucosal immunity, development of tolerance protection against infection. key respiratory gastrointestinal tracts, provide intimate interface between environment self. Normal levels are based on early studies consisting only small numbers patients. The international consensus definition deficiency level 0.07g/l after age four years absence IgG IgM deficiencies. epidemiology reveals interesting variances geographical regions - incidence Caucasians being much higher than that Asians. has also been found to co-exist with autoimmune diseases, allergies malignancies. association autoimmunity particularly because it suggests common genetic linkage could potentially explain diversity geoepidemiology. Both MHC non-MHC associations have described 8.1 haplotype significantly associated patients over controls. Non-MHC include IFIH1 CLEC16A. mutations leading not defined, but some cases suggested pathogenesis failure switched memory B cells can lead this cohort experiencing an increased recurrent bacterial infections or diseases. Attempts investigate cytokines induce synthesis deficiency, such as IL21 combination CD40L/anti-CD40, IL-4 IL10, underway.