Cellular Plasticity in Prostate Cancer Bone Metastasis
作者： Dima Y. Jadaan , Mutaz M. Jadaan , John P. McCabe
DOI: 10.1155/2015/651580
关键词:
摘要: Purpose. Experimental data suggest that tumour cells can reversibly transition between epithelial and mesenchymal states (EMT MET), a phenomenon known as cellular plasticity. The aim of this review was to appraise the clinical evidence for role plasticity in prostate cancer (PC) bone metastasis. Methods. An electronic search performed using PubMed studies have examined differential expression epithelial, mesenchymal, stem cell markers human PC metastasis tissues. Results. included nineteen studies. More than 60% used ≤20 samples, there were several sources heterogeneity Overall, most analysed, except CXCR4, positively expressed tissues, while EMT MET heterogeneous within samples. Several stemness are involved osteomimicry, such Notch, Met receptor, Wnt/β pathway, highly metastases. Conclusions. Clinical findings support cannot be taken isolation when targeting paper also highlights challenges detection
hindawi.com
core.ac.uk 参考文章(80)
L D′Amico, S Patanè, C Grange, B Bussolati, C Isella, L Fontani, L Godio, M Cilli, P D′Amelio, G Isaia, E Medico, R Ferracini, I Roato, Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature British Journal of Cancer. ,vol. 108, pp. 2525- 2536 ,(2013) , 10.1038/BJC.2013.271
Magda Kucia, Ryan Reca, Katarzyna Miekus, Jens Wanzeck, Wojtek Wojakowski, Anna Janowska-Wieczorek, Janina Ratajczak, Mariusz Z. Ratajczak, Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1–CXCR4 Axis Stem Cells. ,vol. 23, pp. 879- 894 ,(2005) , 10.1634/STEMCELLS.2004-0342
Kenneth S. Koeneman, Fan Yeung, Leland W.K. Chung, Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment. The Prostate. ,vol. 39, pp. 246- 261 ,(1999) , 10.1002/(SICI)1097-0045(19990601)39:4<246::AID-PROS5>3.0.CO;2-U
Sajni Josson, Starlette Sharp, Shian-Ying Sung, Peter A. S. Johnstone, Ritu Aneja, Ruoxiang Wang, Murali Gururajan, Timothy Turner, Leland W. K. Chung, Clayton Yates, Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells. Journal of Oncology. ,vol. 2010, pp. 232831- ,(2010) , 10.1155/2010/232831
Sara Previdi, Paola Maroni, Emanuela Matteucci, Massimo Broggini, Paola Bendinelli, Maria Alfonsina Desiderio, Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and β-catenin/Wnt pathways European Journal of Cancer. ,vol. 46, pp. 1679- 1691 ,(2010) , 10.1016/J.EJCA.2010.02.036
Haiyen E. Zhau, Valerie Odero-Marah, Hui-Wen Lue, Takeo Nomura, Ruoxiang Wang, Gina Chu, Zhi-Ren Liu, Binhua P. Zhou, Wen-Chin Huang, Leland W. K. Chung, Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model Clinical & Experimental Metastasis. ,vol. 25, pp. 601- 610 ,(2008) , 10.1007/S10585-008-9183-1
Beatrice S Knudsen, Glenn A Gmyrek, Jennifer Inra, Douglas S Scherr, E Darracott Vaughan, David M Nanus, Michael W Kattan, William L Gerald, George F Vande Woude, None, High expression of the Met receptor in prostate cancer metastasis to bone Urology. ,vol. 60, pp. 1113- 1117 ,(2002) , 10.1016/S0090-4295(02)01954-4
Wei Guo, Dong Ren, Xiuting Chen, Xiang'an Tu, Shuai Huang, Min Wang, Libing Song, Xuenong Zou, Xinsheng Peng, HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145. Journal of Cellular Biochemistry. ,vol. 114, pp. 1606- 1615 ,(2013) , 10.1002/JCB.24502
Rhonda L. Bitting, Daneen Schaeffer, Jason A. Somarelli, Mariano A. Garcia-Blanco, Andrew J. Armstrong, The role of epithelial plasticity in prostate cancer dissemination and treatment resistance Cancer and Metastasis Reviews. ,vol. 33, pp. 441- 468 ,(2014) , 10.1007/S10555-013-9483-Z
Meng‐Lei Zhu, Natasha Kyprianou, Role of androgens and the androgen receptor in epithelial-mesenchymal transition and invasion of prostate cancer cells The FASEB Journal. ,vol. 24, pp. 769- 777 ,(2010) , 10.1096/FJ.09-136994