Comparison of the Antioxidant Properties and the Toxicity of p , p ′-Dichlorodiphenyl Ditelluride with the Parent Compound, Diphenyl Ditelluride

摘要: The hypothesis to be tested in this study is whether the introduction of chloro group into diphenyl ditelluride molecule (p,p′-dichlorodiphenyl ditelluride, compound 1b) alters antioxidant and scavenging activity (compound 1a) vitro. results revealed that 1a 1b had a potent However, functional group, chloro, (1b) did not cause great alterations action against lipid peroxidation, protein carbonyl, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonate) 2,2′-diphenyl-1-picrylhydrazyl radicals. Based on vitro results, different doses (0.25 0.75 µmol/kg) or vehicle (canola oil, 1 ml/kg) were administered rats investigate if presence reduces its toxicity. data demonstrate introduced alter acute oral toxicity rats. administration only altered urea level, while caused all toxicological parameters analyzed (alanine aminotransferase aspartate activities, creatinine levels) plasma present investigation support similar activities rat liver homogenate Furthermore, mortality index but increased