Clinical Aspects and Diagnosis of Thyroid Hormone Transport Protein Anomalies

摘要: The thyroid hormones T4 (thyroxine) and T3 (3, 5, 3′-triiodothyronine) circulate in the blood reversibly bound to proteins. principal transport proteins are: T4-binding globulin (TBG), transthyretin (TTR), formerly called prealbumin or TBPA, albumin. These differ widely concentration their affinity for iodothyronines (Oppenheimer 1968; Robbins Rall 1960; et al. 1986); collectively, they carry more than 99% of serum. Other hormone-binding serum are lipoproteins (Benvenga 1989; Benvenga 1988,1989,1990), example 27 K protein, an apolipoprotein A-I, B-100, which both synthesized liver (Grimaldi 1986; Bartalena 1986a, b). Less important binding immunoglobulin M (Sviridov 1991) and, autoimmune disorders, hormone autoantibodies IgG class 1987).