Identification of changes in tumor secretome upon OV therapy

摘要: A134 Oncolytic viral therapy, which relies on tumor-specific replication and lytic destruction of tumors, is a promising new biologic treatment under evaluation for toxicity efficacy in clinical trials several different tumors. Although have emphasized the safety this approach, biological responses has been complicated by absence reliable biomarker to predict oncolytic virus efficacy. We used syngeneic rat glioma model evaluate changes tumor “secretome” upon OV therapy. Here we describe significant induction CYR61 mRNA infection brain tumors vivo. gene expression was increased animals transiently immune suppressed Cyclophosphamide (CPA) pretreatment indicating its independent host elicited infection. Quantitative Real time PCR verification further revealed linear correlation (Pearsons coefficients, p