Functional Interactions of LFA-1, T8 and Alloantigen Surface Structures in T-Cell Mediated Cytotoxicity

摘要: Monoclonal antibodies (MAb) have provided powerful tools for dissecting the complex cellular interactions involved in lysis of target cells by immune cytotoxic T lymphocytes (CTL). Seven distinct surface-membrane structures been implicated to function cytolytic process mediated human effector virtue ability their MAb inhibit cytolysis absence complement (Table 1). All these inhibitory recognize cell surface present on nonimmune mature lymphoid cells. The Ti, T3, T8 and T4 are unique case define T-cell subpopulations that antigen associated with Class I or II MHC glycoproteins, respectively (1–3). clonotypic (Ti) structure T3 appear form binding recognition CTL (4) whereas Lymphocyte Function Associated Antigen-2 (LFA-2) has identified as sheep red blood rosette receptor (5). In contrast, LFA-1 molecule is both B structurally related OKM1/MAC-1 macrophage glycoprotein which activity (CR3) (6,7). tissue distribution LFA-3 very broad including nonlymphoid