The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes
作者： Valeria Burzomato , Guillaume Frugier , Isabel Pérez-Otaño , Josef T. Kittler , David Attwell
DOI: 10.1113/JPHYSIOL.2010.195503
关键词:
摘要: NMDA receptors have been shown to contribute glutamate-evoked currents in oligodendrocytes. Activation of these damages myelin ischaemia, part because they are more weakly blocked by Mg2+ than most neuronal receptors. This weak block was suggested reflect an unusual subunit composition including the NR2C and NR3A subunits. Here we expressed NR1/NR2C triplet NR1/NR2C/NR3A recombinant HEK cells compared their with those NMDA-evoked rat cerebellar NR1/NR2C/3A were less 2 mm (the remaining current 30% 18%, respectively, that seen without added Mg2+) showed channel noise, suggesting a smaller single conductance. oligodendrocytes (to 32%) similar observed for significantly different from Co-immunoprecipitation revealed interactions between NR1, subunits purified preparation brain. These data consistent reflecting activation containing
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