Enhancement of Frequency Rate of Basolateral Amygdala Neurons Activity by Mglur1 Receptors Agonist in Developmental Schizophrenic Models

摘要: Schizophrenia is a developmental neuropsychiatric disorder which affects nearly 1% of the world population. Disturbances in dopaminergic and glutamatergic transmission have been implicated pathological mechanism this disease. Psychosocial stress form maternal deprivation social isolation (SI) during early postnatal life results long-term effect on neuroendocrine, immune adaptation, disrupt brain development profoundly affect wide-range behaviours adult animals. Recent studies indicated that awake rats, blocker Ionotropic Glutamate receptors increased corticolimbic firing activity. In present study demonstrated alternation single-unit record basolateral amygdala nucleus (BLA) represented activity mGluR1 post-weaning SI. Firing rates injection mGluR1agonist SI states. Short-latency auditory responses (12–25 msec) were found BLA(p