Possible role of adiponectin and insulin sensitivity in mediating the favorable effects of lower body fat mass on blood lipids.
作者： B. Buemann , A. Astrup , O. Pedersen , E. Black , C. Holst
DOI: 10.1210/JC.2005-1062
关键词:
摘要: Aims: The objective of this study was to investigate the role insulin sensitivity and serum adiponectin concentration as determinants, in middle-aged men, relationship between lower body fat blood lipids after truncal has been accounted for. Methods: Men (443) aged 39–65 yr, mass index 18–43 kg/m 2 , participated study. following variables were measured: regional distribution assessed by dual-energy x-ray absorptiometry, maximal oxygen uptake, physical activity, fasting levels adiponectin, triglycerides, high-density lipoproteinand total cholesterol. Plasma glucose measured state an oral load. Results: Lower inversely associated with triglycerides cholesterol positively highdensity lipoprotein-cholesterol adjustment for age, lean tissue mass, weight history, thelevelofphysicalactivity(P0.0005).Serumadiponectinleveland Matsudas intercorrelated, both correlated mass. When including analyses, relationships partly explained. Conclusion: For a given level large is advantageous lipid profile, which may be partially mediated level. (J Clin Endocrinol Metab 91: 1698–1704, 2006)
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