Role in the Enlargement Phase of Cell Growth

摘要: Cell enlargement is a necessary requisite for sustained growth of cells all higher organisms. Close coupling plasma membrane electron transport and was indicated from the beginning with earliest investigations. The mechanistic basis correlation became apparent discovery protein disulfide–thiol interchange activity associated ENOX proteins. Rates cell rates ENOX1 ENOX2 activities in response to activators, inhibitors, anticancer drugs or overexpression are highly correlated. Additionally, periodic major period lengths paralleling those proteins present. Both blocked by thiol reagents. Furthermore, restricted part cycle that alternates oxidative (NADH hydroquinone) portion cycle. Recombinant when incorporated into synthetic lipid vesicles other required constituents (AAA-ATPase, ATP, defined thiol-rich source) recapitulate completely cell-free system. Implicit these findings mechanism both plants animals similar an active process not obligatorily driven biosynthesis turgor. An energy requirement universal met at surface through p97 AAA-ATPase (ATPase Associated Diverse Cellular Activities).