Genetic Polymorphism and Recombination in the Subtelomeric Region of Chromosome 14q
作者： Richard F Wintle , Torbjoern G Nygaard , Jo-Anne S Herbrick , Kirsti Kvaløy , Diane W Cox
关键词:
摘要: Subtelomeric regions of human chromosomes are the sites increased meiotic recombination and have a male-to-female ratio that is higher than elsewhere in genome. We isolated two novel, polymorphic CA repeat markers from distal part immunoglobulin heavy chain gene cluster, approximately 90 200 kb telomere chromosome 14q. The 14q was unambiguously located by physical mapping telomeric YACs Bal31 exonuclease digestion genomic DNA. then constructed haplotypes using genotype data these sCAW1 (D14S826) for use as highly genetic marker. Linkage analysis 40 pedigree CEPH reference panel other loci physically mapped to terminal 1.5 Mb revealed an apparent increase within this region, relative average rate Further, we found females males, indicating subtelomeric region differs regions.
elsevier.com
sci-hub.se 参考文章(31)
G de Lange, M J Johnson, L L Cavalli-Sforza, Ig gamma restriction fragment length polymorphisms indicate an ancient separation of Caucasian haplotypes. American Journal of Human Genetics. ,vol. 38, pp. 617- 640 ,(1986)
J C Benger, D W Cox, Polymorphisms of the immunoglobulin heavy-chain delta gene and association with other constant-region genes. American Journal of Human Genetics. ,vol. 45, pp. 606- 614 ,(1989)
F. Rouyer, A. de la Chapelle, M. Andersson, J. Weissenbach, An interspersed repeated sequence specific for human subtelomeric regions The EMBO Journal. ,vol. 9, pp. 505- 514 ,(1990) , 10.1002/J.1460-2075.1990.TB08137.X
M. H. Hofker, D. W. Cox, M. A. Walter, U. Surti, The physical organization of the human immunoglobulin heavy chain gene complex The EMBO Journal. ,vol. 9, pp. 3303- 3313 ,(1990) , 10.1002/J.1460-2075.1990.TB07530.X
Stylianos Antonarakis, A. Gos, A. Chakravarti, Jean-Louis Blouin, Michael Andréw Morris, D. H. Christie, D. H. Ledbetter, A. Lynn, A new dinucleotide repeat polymorphism at the telomere of chromosome 21q reveals a significant difference between male and female rates of recombination. American Journal of Human Genetics. ,vol. 57, pp. 388- 394 ,(1995)
Hitoshi Nagaoka, Kazuo Ozawa, Fumihiko Matsuda, Hidenori Hayashida, Ryusuke Matsumura, Makoto Haino, Euy Kyun Shin, Yosho Fukita, Takashi Imai, Rakesh Anand, Kazushige Yokoyama, Toshihiko Eki, Eiichi Soeda, Tasuku Honjo, Recent translocation of variable and diversity segments of the human immunoglobulin heavy chain from chromosome 14 to chromosomes 15 and 16 Genomics. ,vol. 22, pp. 189- 197 ,(1994) , 10.1006/GENO.1994.1360
Jonathan Flint, Andrew O.M. Wilkie, Veronica J. Buckle, Robin M. Winter, Anthony J. Holland, Heather E. McDermid, The detection of subtelomeric chromosomal rearrangements in idiopathic mental retardation. Nature Genetics. ,vol. 9, pp. 132- 140 ,(1995) , 10.1038/NG0295-132
Graham P. Cook, Ian M. Tomlinson, The human immunoglobulin VH repertoire Immunology Today. ,vol. 16, pp. 237- 242 ,(1995) , 10.1016/0167-5699(95)80166-9
Richard F Wintle, Teresa Costa, Robert HA Haslam, Ikuko E Teshima, Diane W Cox, None, Molecular analysis redefines three human chromosome 14 deletions. Human Genetics. ,vol. 95, pp. 495- 500 ,(1995) , 10.1007/BF00223859
SUNIL D. PANDIT, JEN C. WANG, ROSALIE A. VEILE, SANTOSH K. MISHRA, CHRISTOPHER A. WARLICK, HELEN DONIS-KELLER, Index, Comprehensive Microsatellite, and Unified Linkage Maps of Human Chromosome 14 with Cytogenetic Tie Points and a Telomere Microsatellite Marker Genomics. ,vol. 29, pp. 653- 664 ,(1995) , 10.1006/GENO.1995.9953