Mechanisms of Environmental and Occupational Carcinogenesis

摘要: Carcinogenesis is a complex, multistep process, involving accumulation of genetic and epigenetic alterations that confer growth and/or survival advantage, through which cells gradually achieve unchecked eventually become fully malignant invasive. There are numerous sources physical, chemical, biological exposures stem from endogenous exogenous sources—including occupational settings—that can induce such alterations. This damage repaired high-fidelity DNA repair process operates multiple pathways, although the system imperfect varies by mechanism, potentially resulting in incorporation chapter provides an introduction to mechanisms environmental carcinogenesis repair, examples physical chemical carcinogens effectors.