Interpreting the Developmental Dance of the Megakaryocyte: A Review of the Cellular and Molecular Processes Mediating Platelet Formation

摘要: Summary Platelets are essential for haemostasis, and thrombocytopenia (platelet counts <150 × 109/l) is a major clinical problem encountered across number of conditions, including immune thrombocytopenic purpura, myelodysplastic syndromes, chemotherapy, aplastic anaemia, human immunodeficiency virus infection, complications during pregnancy delivery, surgery. Circulating blood platelets specialized cells that function to prevent bleeding minimize vessel injury. Platelets circulate in their quiescent form, upon stimulation, activate release granule contents spread on the affected tissue create physical barrier prevents loss. The current model platelet formation states large progenitor bone marrow, called megakaryocytes, by extending long, branching processes, designated proplatelets, into sinusoidal vessels. This review will focus different factors impact megakaryocyte development, proplatelet release. It highlight recent studies thrombopoeitin-dependent maturation, endomitosis formation, cytoskeletal contributions role apoptosis, terminal