Role of Dopamine D1 and D2 Receptors in the Nucleus Accumbens in Mediating Reward

摘要: The objectives of this study were to examine the involvement D1 and D2 receptors within nucleus accumbens (ACB) in mediating reinforcement. intracranial self-administration (ICSA) agonists was used determine whether activating and/or ACB Wistar rats is reinforcing. At concentrations 0.25, 0.50, 1.0 mM (25, 50, 100 pmol/100 nl infusion), neither agonist R(+)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol [SKF 38393 (SKF)] hydrochloride nor (-)-quinpirole (Quin) self-administered into shell region ACB. On other hand, equimolar mixtures SKF Quin (SKF+Quin), at each, significantly self-infused shell. core did not support ICSA SKF+Quin any these concentrations. Rats increased lever pressing when response requirement from a fixed ratio 1 (FR1) FR3, they responded more on infusion than control lever. Coadministration either 0.50 R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4, 5-tetrahydro-1H-3-benzazepine (SCH 23390) hydrochloride, antagonist, or S(-)-sulpiride, completely abolished mixture (each mM) present results suggest that concurrent activation D1- D2-type had cooperative effect DA-mediated reward processes.