The limits of functional reorganization in multiple sclerosis.

摘要: Investigating the brain at rest using functional MRI is a popular new method to investigate function in physiologic and pathologic conditions. Avoiding traditional task-based restrictions, it enables researcher entire with minimal burden has therefore flourished recently, leading discovery of several consistent networks1 that are active healthy performing no task (i.e., rest). One these so-called default-mode network (DMN), which encompasses medial prefrontal, anterior cingulate, posterior cingulate/precuneus, lateral parietal cortices. The DMN was initially identified since frequently deactivated when cognitive tasks, hypothesis this involved postprocessing rest; supporting idea finding completely quiet coma.2 Most current resting state studies focus on have yielded plethora wide spectrum neurologic diseases, like Alzheimer disease (AD), whereas multiple sclerosis (MS) been notably absent until now. Resting alone cannot answer all questions regarding functions. Combining paradigms allows for an optimal assessment states. Normal deactivation regions during tasks is, example, present3 early mild impairment (MCI) stages, combined …