Translational control of localized mRNAs: restricting protein synthesis in space and time

摘要: As highlighted by recent genome-wide analyses in diverse organisms and cell types, subcellular targeting of mRNAs has emerged as a major mechanism for cells to establish functionally distinct compartments structures. For protein synthesis be spatially restricted, translation localizing is silenced during their transport activated when they reach final destination. Such precise pattern controlled repressors, which are specifically recruited ribonucleoprotein particles block at different steps. Functional studies have revealed that the inactivation these either pre-localized proteins or response conserved signalling pathways, triggers local synthesis.