Mitogen activated protein kinases in renal fibrosis

作者: David J Nikolic-Paterson

DOI: 10.2741/S17

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摘要: The mitogen-activated protein (MAP) kinases are involved in both normal renal physiology and the pathology of various forms kidney injury, including fibrosis. In vitro studies have shown a role for all three MAP kinase (ERK, p38 JNK) production major pro-fibrotic factor, transforming growth factor-beta1 (TGF-beta1) by intrinsic cell types. There is also considerable cross-talk between TGF-beta1 signalling pathways synthesis turnover extracellular matrix fibroblast-like cells kidney. addition, contributes to induced transition tubular epithelial into myofibroblasts. Administration specific inhibitors individual has identified pathogenic JNK animal models evidence suggest that activated human Thus, blockade may therapeutic potential treatment chronic

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